ENTHD1

Across TCGA cell cohorts, ENTHD1 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENTHD1-associated genes across cancer lineages are KLRF2, MIOX, and C1QBP. Each is linked with ENTHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENTHD1-to-partner and partner-to-ENTHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRF2 grouped by ENTHD1-low versus ENTHD1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENTHD1→partner) and Y-score (partner→ENTHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KLRF2 →	+0.193	+4.643	<.001	.008	3	1
LARGE_INTESTINE	MIOX →	+0.284	+3.241	.001	.007	3	1
LARGE_INTESTINE	C1QBP →	+0.723	+3.451	.001	.002	3	1
LARGE_INTESTINE	ULBP1 →	+1.478	+3.364	<.001	.002	3	1
LARGE_INTESTINE	RPS12 →	+0.555	+3.364	.002	.002	3	1
LARGE_INTESTINE	PDE10A →	+0.901	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

KLRF2 by ENTHD1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →