ENPP7

Across TCGA cell cohorts, ENPP7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,467 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ENPP7-associated GO terms across cancer lineages are Positive regulation of intestinal cholesterol absorption, Regulation of intestinal cholesterol absorption, and Negative regulation of regulatory T cell differentiation. Each is linked with ENPP7 in more than 4 cancer types. Because this analysis shows association rather than direction, both ENPP7-to-partner and partner-to-ENPP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intestinal cholesterol absorption grouped by ENPP7-low versus ENPP7-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP7→partner) and Y-score (partner→ENPP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of intestinal cholesterol absorption →	-0.238	-0.475	.009	.003	2	5
LIVER	Regulation of intestinal cholesterol absorption →	-0.398	-0.478	.001	.002	3	4
BLOOD_Leukemia	Negative regulation of regulatory T cell differentiation →	+0.067	+0.142	<.001	<.001	3	4
LIVER	Regulation of serotonin secretion →	+1.261	+0.513	.002	.005	3	4
BREAST	Coenzyme A transport →	+0.120	+0.017	<.001	<.001	3	4
BREAST	Coenzyme A transmembrane transport →	+0.120	+0.017	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

Positive regulation of intestinal cholesterol absorption by ENPP7 expression — LIVER

Explore this box plot interactively →