ENPP7

Across TCGA cell cohorts, ENPP7 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ENPP7-associated genes across cancer lineages are LRRC3C, ADAM30, and OOSP4B. Each is linked with ENPP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP7-to-partner and partner-to-ENPP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by ENPP7-low versus ENPP7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP7→partner) and Y-score (partner→ENPP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC3C →	+0.080	+3.796	.003	.008	3	2
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.017	+5.266	<.001	.001	3	1
LUNG_SCLC	C1QA →	+0.234	+3.070	<.001	.009	3	1
LUNG_SCLC	INS →	+0.418	+3.584	<.001	.003	3	1
LUNG_SCLC	OR13C5 →	+0.024	+3.232	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

LRRC3C by ENPP7 expression — BLOOD_Leukemia

Explore this box plot interactively →