ENPP5

Across TCGA patient cohorts, ENPP5 mutation is significantly associated with the RNA expression of many other genes, with 1,658 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP5-associated genes across cancer lineages are RNU6-740P, RNU6-1014P, and PATL1. Each is linked with ENPP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP5-to-partner and partner-to-ENPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-740P grouped by ENPP5-low versus ENPP5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP5→partner) and Y-score (partner→ENPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-740P →	+0.091	+4.003	<.001	.006	3	3
LUAD	RNU6-1014P →	+0.280	+7.930	<.001	.008	3	3
SKCM	PATL1 →	+0.487	+2.526	.004	.009	3	2
SKCM	DAPK3 →	+0.470	+2.813	.004	.001	3	2
UCEC	GLOD4 →	+0.460	+2.470	<.001	<.001	3	2
SKCM	ADAL →	+0.550	+2.604	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,658 associations by consensus.

RNU6-740P by ENPP5 expression — SKCM

Explore this box plot interactively →