ENPP5

Across TCGA patient cohorts, ENPP5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP5-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and Annexin-1. Each is linked with ENPP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP5-to-partner and partner-to-ENPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ENPP5-low versus ENPP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP5→partner) and Y-score (partner→ENPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.297	-2.584	.001	.010	3	2
UCEC	mTOR_pS2448 →	-0.112	-2.308	.046	.033	3	2
UCEC	Annexin-1 →	+0.556	+2.135	.004	.010	3	2
UCEC	VHL →	-0.948	-2.700	<.001	.006	3	2
UCEC	ATM →	-0.494	-1.415	.003	.046	3	2
UCEC	4E-BP1 →	+0.371	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

EGFR_pY1068 by ENPP5 expression — UCEC

Explore this box plot interactively →