ENPP5

Across TCGA cell cohorts, ENPP5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ENPP5-associated genes across cancer lineages are ACSM6, SPACA1, and DPPA2. Each is linked with ENPP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP5-to-partner and partner-to-ENPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by ENPP5-low versus ENPP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP5→partner) and Y-score (partner→ENPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
STOMACH	SPACA1 →	+0.023	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	DPPA2 →	+0.339	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	RPL10L →	+0.191	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	CSN3 →	+0.183	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACSM6 by ENPP5 expression — LARGE_INTESTINE

Explore this box plot interactively →