ENPP3

Across TCGA patient cohorts, ENPP3 mutation is significantly associated with the RNA expression of many other genes, with 5,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP3-associated genes across cancer lineages are MIR4774, MIR7976, and UBE2D2. Each is linked with ENPP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP3-to-partner and partner-to-ENPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by ENPP3-low versus ENPP3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP3→partner) and Y-score (partner→ENPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	3
UCEC	MIR7976 →	+0.280	+1.809	<.001	.003	3	3
UCEC	UBE2D2 →	+0.399	+3.839	.001	<.001	3	3
SKCM	PPRC1 →	+0.325	+2.424	.007	.001	3	3
UCEC	RNF126 →	+0.460	+2.202	<.001	<.001	3	3
UCEC	FCHO2 →	+0.424	+2.606	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,679 associations by consensus.

MIR4774 by ENPP3 expression — READ

Explore this box plot interactively →