ENPP3

Across TCGA patient cohorts, ENPP3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP3-associated genes across cancer lineages are STAT3_pY705, MEK1, and VHL. Each is linked with ENPP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP3-to-partner and partner-to-ENPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ENPP3-low versus ENPP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP3→partner) and Y-score (partner→ENPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.331	-2.237	<.001	.001	3	3
UCEC	MEK1 →	+0.380	+2.459	.002	<.001	3	2
UCEC	VHL →	-0.534	-1.440	.023	.024	3	2
UCEC	Caspase-8 →	-0.264	-4.143	.002	<.001	3	2
UCEC	4E-BP1 →	+0.319	+2.070	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.514	+3.321	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

STAT3_pY705 by ENPP3 expression — UCEC

Explore this box plot interactively →