ENPP2

Across TCGA pan-cancer cohorts, ENPP2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ENPP2 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ENPP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ENPP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where ENPP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.500	1.000	.011	24	view →
LUAD	OS	Median	II,III,IV	0.795	1.000	.005	20	view →
PDAC	OS	Median	II,III,IV	0.960	0.706	<.001	17	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	6	view →
GBM	OS	Median	All	0.797	0.915	.036	1	view →
LSCC	OS	Tertile	All	0.818	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ENPP2–UCEC (OS)

Open the UCEC breakdown →