ENPP2

Across TCGA patient cohorts, ENPP2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,651 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ENPP2-associated genes across cancer lineages are RCAN2, MSRB3, and MEF2C. Each is linked with ENPP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ENPP2-to-partner and partner-to-ENPP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ENPP2 versus RCAN2 in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP2→partner) and Y-score (partner→ENPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCAN2 →	+1.644	+0.805	<.001	<.001	3	7
BRCA	MSRB3 →	+0.981	+0.473	<.001	<.001	3	7
HNSC	MEF2C →	+0.935	+0.378	<.001	.002	3	7
GBM	NALCN →	+1.049	+0.662	<.001	<.001	3	6
UCEC	C7 →	+1.555	+0.465	<.001	<.001	3	6
UCEC	CNRIP1 →	+0.702	+0.382	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,651 associations by consensus.

ENPP2 vs RCAN2 — GBM

Explore this scatter interactively →