ENPP2

Across TCGA patient cohorts, ENPP2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP2-associated genes across cancer lineages are Notch1, PCNA, and PDCD4. Each is linked with ENPP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP2-to-partner and partner-to-ENPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ENPP2-low versus ENPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP2→partner) and Y-score (partner→ENPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.155	+1.643	<.001	.003	3	3
UCEC	PCNA →	+0.190	+1.415	.004	.010	3	3
UCEC	PDCD4 →	-0.346	-1.238	.017	.041	3	3
LUAD	Rab11 →	-0.145	-3.169	.046	.019	3	2
LUSC	p70-S6K →	+0.223	+2.331	.042	.019	3	2
BRCA	STAT3_pY705 →	-0.460	-3.000	.003	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by ENPP2 expression — UCEC

Explore this box plot interactively →