ENPP2

Across TCGA cell cohorts, ENPP2 mutation is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENPP2-associated genes across cancer lineages are HTN1, ACSM2A, and PRAMEF33. Each is linked with ENPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP2-to-partner and partner-to-ENPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN1 grouped by ENPP2-low versus ENPP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP2→partner) and Y-score (partner→ENPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HTN1 →	+0.134	+3.269	<.001	.007	3	2
BLOOD_Myeloma	ACSM2A →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	PRAMEF33 →	+0.016	+4.807	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.160	+3.474	.001	.003	3	1
LARGE_INTESTINE	AKR1A1 →	+0.622	+3.299	.001	.004	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.018	+3.064	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

HTN1 by ENPP2 expression — BLOOD_Leukemia

Explore this box plot interactively →