Across TCGA pan-cancer cohorts, ENPP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENPP1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ENPP1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ENPP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and ESCA are the cancer types where ENPP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.650	.009	26	view →
COAD	DFS	Median	All	0.160	0.797	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.304	0.707	.006	12	view →
GBM	DFS	Median	All	0.060	0.257	.005	6	view →
BLCA	DFS	Median	III,IV	0.210	0.474	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ENPP1 tumor-vs-normal RNA expression · all ENPP1 data types