Across TCGA pan-cancer cohorts, ENPP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ENPP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ENPP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ENPP1 expression acts as an unfavorable survival marker.

PDAC, LSCC, and GBM are the cancer types where ENPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.286	0.482	<.001	69	view →
LSCC	OS	Median	All	0.700	0.914	.001	42	view →
GBM	OS	Quartile	All	0.306	0.683	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ENPP1 tumor-vs-normal RNA expression · all ENPP1 data types