Across TCGA pan-cancer cohorts, ENPP1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ENPP1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ENPP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ENPP1 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC and HNSC are the cancer types where ENPP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENPP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−1.160	<.001	6	view →
HNSC	All	All	−0.312	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ENPP1 RNA expression & survival · all ENPP1 data types