Across TCGA patient cohorts, ENPP1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP1-associated genes across cancer lineages are FASN, ERK2, and INPP4B. Each is linked with ENPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP1-to-partner and partner-to-ENPP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP1→partner) and Y-score (partner→ENPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FASN →	+0.509	+2.331	.010	.019	3	3
UCEC	ERK2 →	+0.191	+2.700	.003	.005	3	2
UCEC	INPP4B →	-0.245	-1.906	.023	.014	3	1
UCEC	JNK_pT183_Y185 →	-0.145	-1.906	.010	.015	3	1
UCEC	JNK2 →	+0.216	+2.727	.001	.002	3	1
UCEC	Ku80 →	+0.251	+2.472	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ENPP1 survival (RNA) · tumor vs normal (RNA) · all ENPP1 data types