Across TCGA cell cohorts, ENPP1 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENPP1-associated genes across cancer lineages are PDE6C, ANKRD40CL, and OR10V1. Each is linked with ENPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP1-to-partner and partner-to-ENPP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP1→partner) and Y-score (partner→ENPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDE6C →	+0.218	+3.302	.002	.008	3	2
SKIN	ANKRD40CL →	+0.038	+4.115	.006	.001	3	1
SKIN	OR10V1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR4N2 →	+0.101	+3.977	<.001	.001	3	1
SKIN	C4orf50 →	+0.020	+4.099	<.001	<.001	3	1
SKIN	OR6J1 →	+0.005	+3.510	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

ENPP1 survival (RNA) · tumor vs normal (RNA) · all ENPP1 data types