ENOPH1

Across TCGA pan-cancer cohorts, ENOPH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENOPH1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ENOPH1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ENOPH1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where ENOPH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.612	0.918	.006	46	view →
CCRCC	OS	Quartile	All	1.000	0.480	.017	19	view →
HNSC	DFS	Quartile	III,IV	0.894	0.628	.007	11	view →
LUAD	OS	Median	All	0.566	0.888	.004	10	view →
UCEC	DFS	Median	All	0.929	0.797	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ENOPH1–LSCC (OS)

Open the LSCC breakdown →