ENO3

Across TCGA patient cohorts, ENO3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENO3-associated genes across cancer lineages are eEF2, Notch1, and Tuberin_pT1462. Each is linked with ENO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENO3-to-partner and partner-to-ENO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ENO3-low versus ENO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENO3→partner) and Y-score (partner→ENO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.393	+3.321	.005	.009	3	2
UCEC	Notch1 →	+0.205	+2.502	<.001	.002	3	2
UCEC	Tuberin_pT1462 →	+0.232	+1.710	.010	.025	3	2
UCEC	14-3-3_beta →	-0.132	-3.558	<.001	.002	3	1
UCEC	EGFR_pY1068 →	-0.340	-3.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.191	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by ENO3 expression — UCEC

Explore this box plot interactively →