ENO3

Across TCGA cell cohorts, ENO3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ENO3-associated genes across cancer lineages are PHOX2B, OR5H6, and ACSM6. Each is linked with ENO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENO3-to-partner and partner-to-ENO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by ENO3-low versus ENO3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENO3→partner) and Y-score (partner→ENO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.017	+4.365	<.001	.002	3	2
CNS	OR5H6 →	+0.022	+4.981	<.001	.008	3	1
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
LARGE_INTESTINE	PFN3 →	+0.123	+3.882	<.001	.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.033	+3.823	<.001	.006	3	1
BLOOD_Leukemia	CPXCR1 →	+0.074	+3.971	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PHOX2B by ENO3 expression — BLOOD_Leukemia

Explore this box plot interactively →