ENO2

Across TCGA patient cohorts, ENO2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENO2-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and Ku80. Each is linked with ENO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENO2-to-partner and partner-to-ENO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ENO2-low versus ENO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENO2→partner) and Y-score (partner→ENO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.275	-3.169	.023	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.595	+3.584	.015	.002	2	2
UCEC	Ku80 →	+0.252	+2.179	.027	.034	3	1
UCEC	MSH6 →	-0.562	-3.321	<.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.222	-3.150	.001	.019	3	1
UCEC	Notch1 →	+0.206	+3.013	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by ENO2 expression — UCEC

Explore this box plot interactively →