ENKD1

Across TCGA patient cohorts, ENKD1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENKD1-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and PDCD4. Each is linked with ENKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENKD1-to-partner and partner-to-ENKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ENKD1-low versus ENKD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENKD1→partner) and Y-score (partner→ENKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.127	-3.000	.022	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-2.571	.027	.011	3	1
UCEC	PDCD4 →	-0.519	-2.999	.017	.035	3	1
UCEC	TIGAR →	+0.159	+2.611	.025	.006	3	1
UCEC	Tuberin →	+0.304	+3.179	.015	.010	3	1
UCEC	ATM →	-0.518	-2.308	.014	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A-Raf_pS299 by ENKD1 expression — UCEC

Explore this box plot interactively →