ENGASE

Across TCGA patient cohorts, ENGASE mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENGASE-associated genes across cancer lineages are Caspase-7-cleavedD198, Tuberin, and Di-Ras3. Each is linked with ENGASE in more than 2 cancer types. Because this analysis shows association rather than direction, both ENGASE-to-partner and partner-to-ENGASE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ENGASE-low versus ENGASE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENGASE→partner) and Y-score (partner→ENGASE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.055	+2.604	<.001	.005	3	3
UCEC	Tuberin →	+0.354	+2.807	.002	.003	3	2
UCEC	Di-Ras3 →	-0.178	-2.115	.005	.019	3	2
UCEC	14-3-3_beta →	-0.142	-3.893	.001	<.001	3	1
UCEC	HER3 →	-0.247	-2.311	.039	.034	3	1
UCEC	Heregulin →	-0.158	-2.321	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by ENGASE expression — UCEC

Explore this box plot interactively →