ENGASE

Across TCGA cell cohorts, ENGASE mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENGASE-associated genes across cancer lineages are PPIAL4F, TARM1, and KCNK18. Each is linked with ENGASE in more than 1 cancer types. Because this analysis shows association rather than direction, both ENGASE-to-partner and partner-to-ENGASE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by ENGASE-low versus ENGASE-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENGASE→partner) and Y-score (partner→ENGASE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPIAL4F →	+0.073	+4.930	<.001	.008	3	2
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
KIDNEY	KCNK18 →	+0.036	+5.000	<.001	.005	3	1
KIDNEY	OR5H6 →	+0.066	+5.000	<.001	.005	3	1
KIDNEY	MTRNR2L10 →	+0.013	+5.000	<.001	.005	3	1
SOFT_TISSUE	OR10V1 →	+0.042	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

PPIAL4F by ENGASE expression — SOFT_TISSUE

Explore this box plot interactively →