ENG

Across TCGA pan-cancer cohorts, ENG mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENG data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ENG mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ENG expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, UCEC, and GBM are the cancer types where ENG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.984	0.365	.001	38	view →
UCEC	DFS	Quartile	II,III,IV	0.372	0.898	.024	8	view →
GBM	OS	Tertile	All	0.371	0.636	.014	6	view →
LSCC	OS	Quartile	II,III,IV	0.501	0.934	.014	5	view →
HNSC	DFS	Quartile	All	0.629	0.844	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ENG–PDAC (DFS)

Open the PDAC breakdown →