ENDOV

Across TCGA patient cohorts, ENDOV mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENDOV-associated genes across cancer lineages are mTOR_pS2448, Annexin-1, and Shc_pY317. Each is linked with ENDOV in more than 1 cancer types. Because this analysis shows association rather than direction, both ENDOV-to-partner and partner-to-ENDOV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ENDOV-low versus ENDOV-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENDOV→partner) and Y-score (partner→ENDOV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.122	-1.986	.012	.029	3	2
UCEC	Annexin-1 →	+0.687	+2.522	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.210	-3.906	<.001	<.001	3	2
UCEC	CD31 →	-0.128	-1.990	.008	.009	3	2
UCEC	Chk2_pT68 →	-0.182	-3.674	.002	.001	3	2
UCEC	eEF2 →	+0.385	+2.115	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

mTOR_pS2448 by ENDOV expression — UCEC

Explore this box plot interactively →