ENDOD1

Across TCGA patient cohorts, ENDOD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENDOD1-associated genes across cancer lineages are GSK-3_pS9, Acetyl-a-Tubulin-Lys40, and Lck. Each is linked with ENDOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENDOD1-to-partner and partner-to-ENDOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by ENDOD1-low versus ENDOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENDOD1→partner) and Y-score (partner→ENDOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.492	-3.000	.015	.036	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.650	+3.009	.010	.019	3	1
UCEC	Lck →	+0.238	+3.000	.018	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.686	-3.169	.003	.019	3	1
UCEC	MEK1 →	+0.540	+2.321	.003	.034	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.523	-3.000	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GSK-3_pS9 by ENDOD1 expression — UCEC

Explore this box plot interactively →