ENC1

Across TCGA patient cohorts, ENC1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENC1-associated genes across cancer lineages are Cyclin-B1, PDCD4, and TFRC. Each is linked with ENC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENC1-to-partner and partner-to-ENC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ENC1-low versus ENC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENC1→partner) and Y-score (partner→ENC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.542	+3.459	.003	.005	3	2
UCEC	PDCD4 →	-0.519	-2.222	<.001	.009	3	2
COAD	TFRC →	+0.782	+2.841	.004	.033	3	2
COAD	ASNS →	+0.773	+3.008	<.001	.019	3	2
UCEC	Lck →	+0.206	+1.321	.002	.029	3	2
UCEC	MEK1 →	+0.435	+3.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Cyclin-B1 by ENC1 expression — UCEC

Explore this box plot interactively →