ENAM

Across TCGA cell cohorts, ENAM mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENAM-associated genes across cancer lineages are TGM6, ZAN, and C1orf87. Each is linked with ENAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ENAM-to-partner and partner-to-ENAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by ENAM-low versus ENAM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENAM→partner) and Y-score (partner→ENAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.015	+4.569	<.001	.003	3	2
PANCREAS	ZAN →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	C1orf87 →	+0.055	+5.000	<.001	.006	3	1
SOFT_TISSUE	LRRC52 →	+0.022	+4.930	<.001	.008	3	1
BLOOD_Leukemia	RHOJ →	+0.390	+3.847	<.001	.004	3	1
BLOOD_Leukemia	DEFB125 →	+0.028	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

TGM6 by ENAM expression — BLOOD_Leukemia

Explore this box plot interactively →