ENAH

Across TCGA cell cohorts, ENAH mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENAH-associated genes across cancer lineages are PRND, OR5B21, and KRTAP13-2. Each is linked with ENAH in more than 2 cancer types. Because this analysis shows association rather than direction, both ENAH-to-partner and partner-to-ENAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRND grouped by ENAH-low versus ENAH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENAH→partner) and Y-score (partner→ENAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	3
CNS	OR5B21 →	+0.057	+2.672	.004	.002	3	2
SOFT_TISSUE	KRTAP13-2 →	+0.013	+4.392	<.001	.004	3	1
CNS	PPBP →	+0.114	+2.736	<.001	.002	3	1
CNS	PF4 →	+0.238	+2.717	<.001	.002	3	1
CNS	RXFP3 →	+0.037	+2.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PRND by ENAH expression — BLOOD_Leukemia

Explore this box plot interactively →