EN2

Across TCGA patient cohorts, EN2 mutation is significantly associated with the RNA expression of many other genes, with 866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EN2-associated genes across cancer lineages are RN7SL309P, MIR4510, and DCP1A. Each is linked with EN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EN2-to-partner and partner-to-EN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL309P grouped by EN2-low versus EN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN2→partner) and Y-score (partner→EN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL309P →	+0.144	+4.812	<.001	.006	3	2
CESC	MIR4510 →	+0.300	+5.342	<.001	.002	3	2
UCEC	DCP1A →	+0.530	+2.321	.004	.006	3	1
UCEC	ZNHIT3 →	+0.456	+3.021	.003	<.001	3	1
UCEC	TAF9 →	+0.685	+3.480	<.001	.002	3	1
UCEC	FRG1HP →	+0.679	+3.721	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 866 associations by consensus.

RN7SL309P by EN2 expression — CESC

Explore this box plot interactively →