EN2

Across TCGA patient cohorts, EN2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EN2-associated genes across cancer lineages are JNK2, Rad50, and STAT3_pY705. Each is linked with EN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EN2-to-partner and partner-to-EN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by EN2-low versus EN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN2→partner) and Y-score (partner→EN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.263	+2.834	.004	.034	3	1
UCEC	Rad50 →	-0.311	-2.584	.005	.011	3	1
UCEC	STAT3_pY705 →	-0.351	-3.169	.004	.018	3	1
UCEC	eIF4E →	+0.205	+2.584	.037	.011	2	1
UCEC	ACC_pS79 →	+0.333	+3.009	.039	.019	2	1
UCEC	Tuberin_pT1462 →	+0.321	+3.331	.002	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by EN2 expression — UCEC

Explore this box plot interactively →