EN2

Across TCGA cell cohorts, EN2 mutation is significantly associated with the mutation status of many other genes, with 4,903 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EN2-associated genes across cancer lineages are CHD2, BICRA, and DAB2IP. Each is linked with EN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EN2-to-partner and partner-to-EN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD2 grouped by EN2-low versus EN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN2→partner) and Y-score (partner→EN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHD2 →	+5.044	+5.614	.003	.003	1	4
CNS	BICRA →	+4.459	+5.277	.005	.005	1	4
LARGE_INTESTINE	DAB2IP →	+2.807	+3.857	<.001	<.001	1	4
SKIN	ERN1 →	+4.824	+5.392	.004	.004	1	3
SKIN	PCDHGA9 →	+5.824	+5.824	.002	.002	1	3
CNS	CAPN14 →	+4.044	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,903 associations by consensus.

CHD2 by EN2 expression — CNS

Explore this box plot interactively →