EN1

Across TCGA patient cohorts, EN1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,310 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EN1-associated genes across cancer lineages are ITGB8, NPR3, and TMCC2. Each is linked with EN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EN1-to-partner and partner-to-EN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EN1 versus ITGB8 in HNSC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN1→partner) and Y-score (partner→EN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ITGB8 →	+1.390	+0.833	.002	.001	3	2
HNSC	NPR3 →	+1.646	+0.787	.001	.002	3	2
BRCA	TMCC2 →	+1.253	+1.748	<.001	<.001	3	2
HNSC	MAP3K21 →	+1.425	+1.074	.001	.001	3	2
BRCA	UBE2E3 →	+0.879	+0.992	.005	.004	3	2
BRCA	ILF2P1 →	+1.220	+1.042	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,310 associations by consensus.

EN1 vs ITGB8 — HNSC

Explore this scatter interactively →