EN1

Across TCGA patient cohorts, EN1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EN1-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and MEK1. Each is linked with EN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EN1-to-partner and partner-to-EN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by EN1-low versus EN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN1→partner) and Y-score (partner→EN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.367	+3.000	<.001	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-2.990	.034	.036	3	1
UCEC	MEK1 →	+0.536	+3.169	.007	.020	3	1
UCEC	PEA-15_pS116 →	+0.610	+3.000	.001	.036	2	2
UCEC	Stathmin →	+0.205	+3.169	.006	.020	3	1
UCEC	TIGAR →	+0.198	+3.196	.018	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by EN1 expression — UCEC

Explore this box plot interactively →