EN1

Across TCGA cell cohorts, EN1 mutation is significantly associated with the mutation status of many other genes, with 334 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EN1-associated genes across cancer lineages are KCNV1, ZNF148, and ARHGAP12. Each is linked with EN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EN1-to-partner and partner-to-EN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNV1 grouped by EN1-low versus EN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EN1→partner) and Y-score (partner→EN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNV1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	ZNF148 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	ARHGAP12 →	+6.014	+6.014	.001	.001	1	2
BLOOD_Lymphoma	MGAT5B →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	KBTBD2 →	+6.014	+6.014	.001	.001	1	2
BLOOD_Lymphoma	KCNG3 →	+6.014	+6.014	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

KCNV1 by EN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →