EMX2

Across TCGA patient cohorts, EMX2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMX2-associated genes across cancer lineages are JNK_pT183_Y185, p27_pT198, and p62 Lck ligand. Each is linked with EMX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMX2-to-partner and partner-to-EMX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by EMX2-low versus EMX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMX2→partner) and Y-score (partner→EMX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.168	-3.169	.046	.019	3	1
UCEC	p27_pT198 →	+0.115	+3.459	.032	.005	3	1
UCEC	p62 Lck ligand →	+0.358	+2.817	.028	.036	3	1
UCEC	STAT3_pY705 →	-0.416	-2.311	.001	.034	3	1
UCEC	AR →	-0.392	-3.000	.036	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.092	+3.341	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK_pT183_Y185 by EMX2 expression — UCEC

Explore this box plot interactively →