EMX1

Across TCGA patient cohorts, EMX1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMX1-associated genes across cancer lineages are Akt, EGFR_pY1173, and IGFBP2. Each is linked with EMX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMX1-to-partner and partner-to-EMX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by EMX1-low versus EMX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMX1→partner) and Y-score (partner→EMX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.291	-3.000	.027	.037	3	2
UCEC	EGFR_pY1173 →	+0.097	+3.026	.035	.019	3	1
UCEC	IGFBP2 →	-0.762	-3.000	.042	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.712	-2.986	.006	.037	3	1
UCEC	Tuberin_pT1462 →	-0.330	-3.000	.013	.037	2	2
UCEC	MIG-6 →	+0.174	+3.013	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Akt by EMX1 expression — UCEC

Explore this box plot interactively →