EMSY

Across TCGA patient cohorts, EMSY mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMSY-associated genes across cancer lineages are Caspase-7-cleavedD198, STAT3_pY705, and c-Met_pY1235. Each is linked with EMSY in more than 3 cancer types. Because this analysis shows association rather than direction, both EMSY-to-partner and partner-to-EMSY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EMSY-low versus EMSY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMSY→partner) and Y-score (partner→EMSY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.525	+1.522	.004	.017	3	4
UCEC	STAT3_pY705 →	-0.349	-2.237	<.001	.001	3	3
UCEC	c-Met_pY1235 →	+0.064	+1.594	.005	.005	3	3
BLCA	Ku80 →	+0.426	+3.459	.006	.005	3	2
BLCA	SETD2 →	-0.178	-3.459	.021	.005	3	2
BLCA	53BP1 →	+0.360	+2.339	.028	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by EMSY expression — UCEC

Explore this box plot interactively →