EMSY

Across TCGA cell cohorts, EMSY mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EMSY-associated genes across cancer lineages are RBMY1A1, DEFB134, and SH3GL2. Each is linked with EMSY in more than 1 cancer types. Because this analysis shows association rather than direction, both EMSY-to-partner and partner-to-EMSY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by EMSY-low versus EMSY-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMSY→partner) and Y-score (partner→EMSY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
BREAST	DEFB134 →	+0.140	+4.199	<.001	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.954	+3.474	<.001	.003	3	1
LARGE_INTESTINE	REG1B →	+2.942	+2.933	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.029	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RBMY1A1 by EMSY expression — OVARY

Explore this box plot interactively →