Across TCGA patient cohorts, EMP2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMP2-associated genes across cancer lineages are c-Met_pY1235, Notch1, and S6_pS235_S236. Each is linked with EMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMP2-to-partner and partner-to-EMP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMP2→partner) and Y-score (partner→EMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.073	+2.115	.025	.019	3	2
UCEC	Notch1 →	+0.159	+2.183	.009	.033	3	1
UCEC	S6_pS235_S236 →	+0.466	+3.321	.013	.009	3	1
UCEC	STAT3_pY705 →	-0.445	-2.115	<.001	.019	3	1
UCEC	Tuberin_pT1462 →	+0.268	+2.469	.007	.010	3	1
UCEC	Tuberin →	+0.302	+2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

EMP2 survival (RNA) · tumor vs normal (RNA) · all EMP2 data types