Across TCGA patient cohorts, EML6 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML6-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and CD49b. Each is linked with EML6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML6-to-partner and partner-to-EML6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML6→partner) and Y-score (partner→EML6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.469	-3.000	.005	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.450	+1.434	.004	.005	3	2
UCEC	CD49b →	-0.165	-1.269	.030	.021	3	2
UCEC	14-3-3_beta →	-0.074	-1.295	.005	.024	3	1
UCEC	EGFR_pY1068 →	-0.181	-1.502	.006	<.001	3	1
UCEC	A-Raf_pS299 →	-0.086	-1.222	.006	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

EML6 survival (RNA) · tumor vs normal (RNA) · all EML6 data types