EML5

Across TCGA patient cohorts, EML5 mutation is significantly associated with the RNA expression of many other genes, with 5,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML5-associated genes across cancer lineages are C12orf43, PBK, and ASB8. Each is linked with EML5 in more than 3 cancer types. Because this analysis shows association rather than direction, both EML5-to-partner and partner-to-EML5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf43 grouped by EML5-low versus EML5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML5→partner) and Y-score (partner→EML5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C12orf43 →	+0.236	+1.776	<.001	<.001	3	4
UCEC	PBK →	+0.891	+2.180	<.001	<.001	3	4
UCEC	ASB8 →	+0.316	+2.066	.001	<.001	3	4
UCEC	BIRC5 →	+0.756	+1.991	<.001	<.001	3	4
COAD	COX6A1P2 →	+0.869	+2.820	.005	.001	3	4
UCEC	CDKN3 →	+0.792	+1.970	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,220 associations by consensus.

C12orf43 by EML5 expression — UCEC

Explore this box plot interactively →