EML5

Across TCGA cell cohorts, EML5 mutation is significantly associated with the RNA expression of many other genes, with 1,362 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EML5-associated genes across cancer lineages are DAZ2, DDHD1, and ELP3. Each is linked with EML5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML5-to-partner and partner-to-EML5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by EML5-low versus EML5-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML5→partner) and Y-score (partner→EML5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DAZ2 →	+1.250	+5.169	<.001	<.001	3	2
LARGE_INTESTINE	DDHD1 →	+0.812	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ELP3 →	+0.614	+2.850	.001	<.001	3	2
LARGE_INTESTINE	DCAF1 →	+0.452	+2.158	.002	.004	3	2
CNS	WFDC10A →	+0.101	+3.145	<.001	.004	3	2
OVARY	LCE5A →	+0.073	+2.736	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,362 associations by consensus.

DAZ2 by EML5 expression — STOMACH

Explore this box plot interactively →