EML4

Across TCGA pan-cancer cohorts, EML4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of EML4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where EML4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EML4 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, COAD, and HNSC are the cancer types where EML4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EML4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.627	<.001	9	view →
COAD	Male	III,IV	+0.337	<.001	9	view →
HNSC	Male	IV	+0.672	<.001	8	view →
CCRCC	Male	II,III,IV	+0.210	<.001	8	view →
PDAC	All	All	−0.255	.002	4	view →
LSCC	All	All	+0.137	<.001	4	view →
OV	All	All	+0.449	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

EML4–LUAD

Open the LUAD breakdown →