EML4

Across TCGA patient cohorts, EML4 mutation is significantly associated with the RNA expression of many other genes, with 3,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML4-associated genes across cancer lineages are MIR3661, ATXN3L, and RNU1-150P. Each is linked with EML4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EML4-to-partner and partner-to-EML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by EML4-low versus EML4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML4→partner) and Y-score (partner→EML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3661 →	+1.484	+3.829	<.001	.005	3	3
CESC	ATXN3L →	+0.021	+4.837	<.001	.003	3	2
ESCA	RNU1-150P →	+0.282	+4.285	<.001	.006	3	2
ESCA	MTCYBP9 →	+0.447	+4.068	<.001	.002	3	2
ESCA	MTND3P4 →	+0.115	+4.285	<.001	.006	3	2
ESCA	MTND5P30 →	+0.359	+3.726	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

MIR3661 by EML4 expression — COAD

Explore this box plot interactively →