EML4

Across TCGA patient cohorts, EML4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML4-associated genes across cancer lineages are Cyclin-B1, mTOR_pS2448, and p62 Lck ligand. Each is linked with EML4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EML4-to-partner and partner-to-EML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by EML4-low versus EML4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML4→partner) and Y-score (partner→EML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.788	+3.058	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.174	-3.156	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.376	+2.009	<.001	.005	3	2
UCEC	PCNA →	+0.294	+2.584	<.001	<.001	3	2
UCEC	PDCD4 →	-0.517	-1.492	.001	.027	3	2
UCEC	Stathmin →	+0.110	+1.321	.016	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Cyclin-B1 by EML4 expression — UCEC

Explore this box plot interactively →