EML4

Across TCGA cell cohorts, EML4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,844 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EML4-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, RNA export from nucleus, and Establishment of RNA localization. Each is linked with EML4 in more than 11 cancer types. Because this analysis shows association rather than direction, both EML4-to-partner and partner-to-EML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by EML4-low versus EML4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EML4→partner) and Y-score (partner→EML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	5S class rRNA transcription by RNA polymerase III →	+0.098	+1.754	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	RNA export from nucleus →	+0.084	+1.013	.006	<.001	3	12
BLOOD_Lymphoma	Establishment of RNA localization →	+0.098	+1.134	<.001	<.001	3	11
KIDNEY	RNA localization →	+0.076	+1.149	<.001	.001	3	11
KIDNEY	Regulation of chromatin organization →	+0.082	+0.892	.005	.002	3	11
OVARY	Nuclear export →	+0.061	+0.743	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

5S class rRNA transcription by RNA polymerase III by EML4 expression — SOFT_TISSUE

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