EML4

Across TCGA cell cohorts, EML4 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EML4-associated genes across cancer lineages are LY6L, GNAT1, and TRPC5. Each is linked with EML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML4-to-partner and partner-to-EML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6L grouped by EML4-low versus EML4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML4→partner) and Y-score (partner→EML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LY6L →	+0.021	+3.944	<.001	.006	3	2
BLOOD_Leukemia	GNAT1 →	+0.054	+3.855	.002	.007	3	2
LUNG_NSCLC_LUAD	TRPC5 →	+0.007	+2.882	<.001	.009	3	2
OESOPHAGUS	FHL5 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Leukemia	H2BW2 →	+0.097	+4.234	<.001	.003	3	1
BLOOD_Leukemia	GML →	+0.104	+4.567	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

LY6L by EML4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →