EML3

Across TCGA patient cohorts, EML3 mutation is significantly associated with the RNA expression of many other genes, with 1,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML3-associated genes across cancer lineages are RN7SL447P, RN7SL505P, and SPANXN2. Each is linked with EML3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EML3-to-partner and partner-to-EML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by EML3-low versus EML3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML3→partner) and Y-score (partner→EML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL447P →	+0.217	+5.201	<.001	.007	3	3
HNSC	RN7SL505P →	+0.190	+3.904	.006	.007	3	2
HNSC	SPANXN2 →	+0.024	+4.883	<.001	.004	3	2
SKCM	DHRSX →	+0.456	+3.497	.005	.002	3	2
UCEC	PHLDA2 →	+0.814	+2.212	.005	<.001	3	2
UCEC	RNU1-17P →	+0.134	+2.061	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,704 associations by consensus.

RN7SL447P by EML3 expression — CESC

Explore this box plot interactively →